Smith Research Lab
All Publications
2022
Jacqueline Smith, Mayowa Osunsanya, Ikechi Nwadike, Brenda Belwood Microwave-assisted Groebke-Blackburn-Bienayme’ (GBB) Synthesis of Imidazoles using Acyclic Amidines. Tetrahedron Letters 2022, 100, 153876.
2020
Jacqueline A. Smith, Mia B. Russell. Striving Towards Improving Underrepresented Minority Success in Organic Chemistry: Self-Efficacy and Deep-Learning Strategies. Understanding Interventions 2020, 11(2), 17871-
2016
Jacqueline Smith, Yali Kong, Kongwen Li, Jake Cui, John Han, Shujie Hou, Milton Brown. Development of a novel near-infrared fluorescent theranostic Combretastin A-4 analogue, YK-5-252, to target triple negative breast cancer. Bioorg Med Chem 2016, 25 (7), 2226-2233.
2016
Lanier Heyburn, Michaeline Hebron, Jacqueline Smith, Charisse Winston, John Bechara, Zhaoxia Li, Irina Lonskaya, Mark P. Burns, Brent Harris, Charbel E-H Moussa. Tyrosine kinase inhibition reverses alterations of astrocytic function and amino acid dis-homeostasis in mice expressing neuronal TDP-43. Neurochem 2016 Nov; 139(4): 610-623
2013
Jung-Hye Ha, Yumi Eo, Alexander Grishaev, Min Guo, Jacqueline A.I. Smith, Herman Sintim, Eun-Hee Kim, Hae-Kap Cheong, William Bentley, Kyoung-Seok Ryu. Crystal structures of the LsrR proteins complexed with phospho-AI-2 and two signal-interrupting analogs reveal distinct mechanisms for ligand recognition. Amer. Chem. Soc. 2013, 135 (41), 15526–15535.
2013
Varnika Roy, Mariana T. Meyer, Jacqueline A.I. Smith, Sonja Gamby, Herman O. Sintim, Reza Ghodssi, William E. Bentley. AI-2 analogs and antibiotics: A synergistic approach to reduce bacterial biofilms in a microfluidic setting. Microbiol. Biotechnol. 2013, 97 (6), 2627-2638.
2012
Sonja Gamby, Varnika Roy, Min Guo, Jacqueline A.I. Smith, Jingxin Wang, Jessica E. Stewart, Xiao Wang, William E. Bentley, Herman O. Sintim. Altering the communication networks of multispecies microbial systems using a diverse toolbox of AI-2 analogs. ACS Chem. Bio. 2012, 7 (6), 1023-1030.
2012
Min Guo, Sonja Gamby, Shizuka Nakayama, Jacqueline A.I. Smith, Herman O. Sintim. A pro-drug modulation of AI-2 mediated bacterial cell-to-cell communication. Sensors 2012, 12(3), 3762-3772.
2011
Kishore Kamaraju, Jacqueline A.I. Smith, Jingxin Wang, Varnika Roy, Herman O. Sintim, William E. Bentley, Sergei Sukharev. Effects on membrane lateral pressure suggest permeation mechanisms for bacterial quorum signaling molecules. Biochemistry 2011, 50 (32), 6983-6993.
2010
Jacqueline A.I. Smith, Varnika Roy, Jingxin Wang, Jessica E. Stewart, William E. Bentley, Herman O. Sintim. Synthetic analogs tailor native AI-2 signaling across bacterial species. J. Amer. Chem. Soc. 2010, 132 (32), 11141–11150.
2010
Herman O Sintim, Jacqueline A.I. Smith, Jingxin Wang, Shizuka Nakayama, Lei Yan. Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules Future Med Chem. 2010, 2 (6), 1005-1035.
2010
Jingxin Wang, Bogdan Stefane, Deana Jaber, Jacqueline A.I. Smith, Christopher Vickery, Mouhamed Diop and Herman O. Sintim. Remote C-H Functionalization: Using the N-O Moiety as an Atom-Economical Tether to Obtain 1,5- and the Rare 1,7-C-H Insertions. Chem. Int. Ed. 2010, 49, 3964-3968.
2009
Jacqueline A.I. Smith, Jingxin Wang, Sao-Mai Nguyen-Mau, Vincent Lee and Herman O. Sintim. Biological screening of a diverse set of AI-2 analogs in Vibrio harveyi suggests that receptors, which are involved in synergistic agonism of AI-2 and analogs are promiscuous. Chem. Commun. 2009, 7033-7035